Description

A 72-year-old man with normal pressure hydrocephalus to our hospital with a history of productive cough, sputum, fever, dyspnea combined with nasal cannula oxygen therapy, chest radiography, vital signs: Total leukocyte count of 11800/cmm and Erythrocyte Sedimentation Rate (ESR) 53 mm in the first hour using Westergren method, C-reactive protein (CRP) 11.2 mg/dl [1]. The intravenous infusion of a solution consisting of 250mL normal saline with of potassium chloride (KCl) over 6 h , vitamin C intake with supportive care resulted in recovery, intramuscular injections of the graphene previously [2,3]. After the injection, ESR, CRP was 40-1.91 and segmental neutrophil was 79.6%. Alveolar epithelial cells underwent Epithelial-Mesenchymal Transition (EMT) in the progression of Acute Interstitial Pneumonia (AIP). AIP is characterized by acute respiratory prodrome including sore throat, headache, cough, dyspnea, and often fever with abrupt onset and short duration . AIP was defined Diffuse Alveolar Damage (DAD). The pathologic progress of DAD three phases: acute exudative phase, characterized by interstitial edema, hyaline membrane, and acute interstitial inflammation accumulation; proliferative phase,characterized by in alveolar spaces; and fibrotic phase,characterized by enlarged fibrotic septa and laminated intra-alveolar fibrosis. Epithelial-mesenchymal transition defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype [4].

Figure 1: After NACl + KCl for 3 days

Figure 2: QT corrected interval of 437 milliseconds.

References

1. Yanyan Liao, Weiyi Wang, Yongyan Sun, Shen Tian, Peng Cai. Reduced graphene oxide triggered epithelial-mesenchymal transition in A549 cells, Scientific Reports. 2018; 8: 15188.
2. Chin C. Changes in electrocardiogram after intramuscular injection of graphene using saltintercalation exfoliation, J Clin Exp Cardiol. 2023; 14: 1-15.
3. Chin C. Cell entry inhibitor with sulfonated colloid gold as new potent broad spectrum virucides, J Infect Dis Ther. 2021; 9: 1-4.
4. Li et al. Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: A case report, BMC Pulmonary Medicine. 2014; 14: 67.