Journal of Clinical Images and Medical Case Reports

ISSN 2766-7820
Case Report - Open Access, Volume 2

Madelung’s disease: A case report of laryngeal localization and a review of the literature

Fabrizia Elli1 *; Marco Stacchini2 ; Alberto Daniele Arosio1,5; Roberta Priola3 ; Tommaso Mazzocco4 ; Marco Limarzi2

1Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

2Division of Otorhinolaryngology, M. Bufalini Hospital, Cesena, Italy

3Division of Otorhinolaryngology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy

4Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Italy.

5PhD student, Biotechnologies and Life Sciences, University of Insubria, Varese, Italy.

*Corresponding Author: Fabrizia Elli
Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Via Guicciardini 9, 21100, Varese, Italy.
Email: [email protected]

Received : May 01, 2021

Accepted : Jun 01, 2021

Published : Jun 03, 2021

Archived : www.jcimcr.org

Copyright : © Elli F (2021).

Abstract

Madelung’s Disease (MD), also known as benign multiple symmetric lipomatosis or Launois-Bensaude syndrome, is a rare condition. The characteristic feature is the presence of numerous diffuse lipomas at the level of the neck or upper limbs. The etiology is unknown, but a close association with ethyl abuse has been observed. The use of radiological examinations such as ultrasound, computed tomography and magnetic resonance imaging is helpful for the differential diagnosis. There are two classifications mainly used: The Enzi classification and the Donhauser classification. In this article we present a case of MD with laryngeal localization. A 50-year-old man was referred to our department complaining of dysphonia for about 6 months. An abnormal and diffuse enlargement of the anterior part of the neck was noticed, compatible with “Madelung’s Collar”. Fiberoptic examination of the larynx revealed the presence of a lipomatous-like neoformation of the left false vocal cord. The patient underwent surgical removal of the laryngeal neoformation with transoral laser microsurgery. With this article we suggest a possible diagnostic and therapeutic procedure for the treatment of laryngeal lipomatosis.

Keywords: Lipoma; TML; Larynx; Dysphonia; ENT

Citation: Elli F, Stacchini M, Arosio AD, Priola R, Mazzocco T, et al. Madelung’s disease: A case report of laryngeal localization and a review of the literature. J Clin Images Med Case Rep. 2021; 2(3): 1181.

Introduction

Madelung’s Disease (MD), also known as Launois-Bensaude syndrome or multiple symmetric lipomatosis and benign symmetric lipomatosis [1], is a rare condition, with a prevalence of 1: 25,000. It mainly affects males living in the Mediterranean area, with a male: female ratio 15-30: 1 [2]. It presents with the appearance of diffuse lipomas in the proximal upper limbs and neck. The etiology is unknown, but it seems that catecholamines have a fundamental role in promoting the process of lipogenesis [3] and an association with chronic alcoholism (60- Abstract Madelung’s Disease (MD), also known as benign multiple symmetric lipomatosis or Launois-Bensaude syndrome, is a rare condition. The characteristic feature is the presence of numerous diffuse lipomas at the level of the neck or upper limbs. The etiology is unknown, but a close association with ethyl abuse has been observed. The use of radiological examinations such as ultrasound, computed tomography and magnetic resonance imaging is helpful for the differential diagnosis. There are two classifications mainly used: The Enzi classification and the Donhauser classification. In this article we present a case of MD with laryngeal localization. A 50-year-old man was referred to our department complaining of dysphonia for about 6 months. An abnormal and diffuse enlargement of the anterior part of the neck was noticed, compatible with “Madelung’s Collar”. Fiberoptic examination of the larynx revealed the presence of a lipomatous-like neoformation of the left false vocal cord. The patient underwent surgical removal of the laryngeal neoformation with transoral laser microsurgery. With this article we suggest a possible diagnostic and therapeutic procedure for the treatment of laryngeal lipomatosis. Keywords: Lipoma; TML; Larynx; Dysphonia; ENT. 90% of patients) is reported [4]. In its classic form, a specific sign is represented by an important flaring at the level of the anterior neck, which is known as Madelung collar or horse collar [5,6]. Diagnosis is based on the patient’s history and physical examination, while imaging in the form of ultrasound, computed tomography and magnetic resonance, can help in the differential diagnosis. In this report, we present a case of laryngeal MD and share our experience in its treatment.

Case report

A 50-year-old man presented with a 6-month history of mild dysphagia and progressive dyspnea. Flexible transnasal endoscopy revealed a cystic growth originating from the left ventricle, partially projected into the lumen, with partial reduction of the respiratory space. The lesion was approximately 1.5 cm in diameter, translucent in appearance and covered with normal mucosa (Figure 1a). Both vocal cords were moble and hypopharyngeal and laryngeal anatomy showed no other abnormalities. CT scan showed hypertrophy of the paraglottic adipose tissue at the level of the left false vocal cord, extended up to its free edge (Figure 2). Neck US showed hypertrophic - hyperechoic tissue apparently of lipomatous nature at the level of the neck and the parotid. Indication to surgical removal via Transoral Laser Microsurgery (TLM) was given. The size of the lesion and its welldefined border allowed for complete surgical excision. At the end of the procedure, a continuous wave laser treatment on the excisional margins and on the wound bed was performed [7], in order to prevent possible relapses (Figure 3).

The patient was discharged the day after the surgery, reporting neither dysphagia nor breathing difficulties. Pathological examination revealed a 1.5 cm lipomatous formation with focal spindle cells, without atypia. After 2 months, no recurrence was noticed (Figure 1b).

Figure 1: Pre and postoperative examination of the lesion with flexible laryngoscopy. (a) 1 cm neoformation of the left ventricle, projecting into the lumen. (b) At the 2-month follow-up visit, no recurrence or airway obstruction was found.

Figure 2: Computed Tomography (CT) of the lesion. A plain CT scan of the neck showed a well-circumscribed very-low-density mass located on the left false vocal cord. Transverse CT image.

Figure 3: Removal of tumor. (a) Before the operation. (b) The lesion was completely resected by TLM with CO2 laser with post margin photocoagulation. lobe

Discussion

MD is a rare disease the pathophysiology of which is still unknown. Various theories have been proposed: A defect in the lipolytic pathway in response to catecholamines [3] or mutations or deletions of mitochondrial DNA [8]. Two different classifications are used in clinical practice: the classification by Enzi et al [9], based on the anatomical distribution of fat, and the more recently proposed by Donhauser et al [10]. Enzi's classification defines two categories: type 1, in which the distribution of fat is symmetrical and mainly involves neck, shoulders, supraclavicular triangle and proximal upper limbs and type 2, in which fat deposits are localized in the abdomen and thighs (also typical of the patient with classical obesity). The Donhauser classification defines three types of MD: Type 1 - neck distribution, type 2 - pseudo-athletic appearance and type 3 - gynecological appearance (Table 1).

Table 1: Enzi and Donhauser classification of Madelung's disease.

Enzi

Donhauser

Affected body areas

Type 1

Type I (horse collar)

Neck, upper back, shoulder girdle, and upper arms

Type II (pseudo athletic type)

Shoulder girdle, deltoid region, upper arms, and thorax

Type III (gynecoid type)

Lower body, especially the thighs and medial side of the knees

Type 2

Type IV (abdominal type)

Abdomen

The use of imaging is an aid in the diagnosis. CT scans primarily evaluate the size and location of the growth, while MRI provides superior definition of the soft tissues [11] allowing for better delineation of the extent and localization of the mass. On MRI, MD-related fat appears as unencapsulated and distributed along the vascular / muscular planes. On the contrary, the classic lipomas are localized in the subcutaneous space with an unencapsulated appearance.

Differential diagnosis encompasses other pathologies such as angiolipoma, neurofibroma, liposarcoma, lipoblastomatosis, lipodystrophy, lymphoma, neurofibromatosis and diseases of the salivary glands. Lipomas usually grow slowly and might cause aesthetic problems, rarely causing mass effect on surrounding structures, with symptoms depending upon their size and location. Laryngeal lipomas are rare, representing around 0.6% of all benign lesions of the larynx [12]. Given their location, they can be responsible for pharyngodynia, hoarseness, dyspnea and dysphagia. To date, 73 clinical cases of laryngeal lipomas have been found in the literature (Table 2).

Table 2: Summary of reported cases of endolaryngeal lipoma from 1994 to today.

Author

Country

No. pts.

Age/ sex

Site

Symptoms

Eckel and Jungehülsing, [23] 1994

Germany

3

-

Hypopharynx

-

Zbären et al, [23] 1995

Switzerland

1

47/M

Larynx

-

Wenig et al, [23] 1995

USA

3

28/F
51/F
51/M

Supraglottic larynx (n = 2) and piriform sinus

Airway obstruction, dysphagia, throat discomfort, sensation of excessive secretion in the throat

Welinder et al, [23] 1996

Denmark

1

-

Vallecula epiglottica

Fatal airway obstruction

Anand, [13] 1997

India

1

48/M

Right aryepiglottic fold

Intermittent respiratory obstruction

Mevio et al, [14] 1997        

Italy

1

-

Larynx

-

Gao et al, [23] 1997

China

1

-

Hypopharynx

Dysphagia, throat discomfort, and airway obstruction

Yoskovitch et al, [15] 1999

Canada

1

-

-

-

Barry et al, [23] 2000

France

5

M/F

Hypopharynx and larynx

-

Jungehülsing et al, [23] 2000

Germany

7

M/F

Hypopharynx and larynx

-

Maged and Riad, [23] 2000

Scotland

1

50/M

Larynx

Hoarseness and dyspnea

Srinivasan and Davies, [23] 2000

UK

1

57/M

Pharynx and larynx

Snoring and intermittent choking

Nishiyama et al, [23] 2001

Japan

1

82/F

Hypopharynx

Wheezing and intermittent breathlessness

Grützenmacher et al, [23] 2002

Germany

1

42/M

Left aryepiglottic fold

Throat discomfort and airway obstruction

Lippert et al, [23] 2002

Germany

2

-/-

-

-

Miloudi et al, [23] 2005

Morocco

1

57/F

Epiglottis

Dyspnea and dysphagia

Singhal et al, [23] 2005

India

1

56/F

Epiglottis

Fatal airway obstruction

Dereköy et al, [23] 2007

Turkey

1

63/F

Tonsil

Confusion, disorientation, and difficult intubation

Jawar et al, [17] 2007

India

1

63/M

Right arytenoid

Change of voice

Mitchell et al, [23] 2007

UK

1

62/F

Oropharynx

Stridor

Mattioli et al, [23] 2008

Brazil

1

58/M

Larynx

Hoarseness and dyspnea

Minni et al, [23] 2008

Italy

1

48/M

Paraglottic space

Hoarseness and soft voice

De Vincentis et al, [23] 2010

Italy

1

62/M

Right ary-epiglottic fold

Dyspnea, dysphonia

Mohammad et al, [23] 2010

Iran

1

41/M

Right supraglottic larynx

Voice change and dyspnea

Megan et al, [20] 2010

England

1

-/-

Larynx

-

Eyigor et al, [23] 2011

Turkey

1

60/M

Vocal fold and vocal process of the arytenoids

Hoarseness

Lee DH et al, [16] 2011        

Korea

1

-

Larynx             

Dyspnea

Nader et al, [23] 2012

Iran

1

63/M

Right aryepiglottic fold

Intermittent stridor and snoring

Landínez-Cepeda et al, [21] 2012

Spain

1

-/M

Larynx             

Dyspnea

Lee HS et al, [22] 2013

Taiwan

4

-/M    56/M   57/M   50/M

Glottic larynx (n = 3) and larynx

Dyspnea, stridor, neck swelling, dysphonia

D’antonio et al, [24] 2013

Italy

1

65/M

Left true vocal fold

Hoarseness, choking spells, stridor, dyspnea

Cáceres et al, [25] 2013

Spain

1

-/-

Pharyngoepiglottic

-

Sotirović et al, [26] 2014

Serbia

1

-

Hypopharynx

-

Kodiyan et al, [27] 2015

USA

2

58/M     79/F

Larynx               

Shortness of breath, dysphagia, and globus sensation. Non-progressive hoarseness and globus sensation                                                                                                                                              

Tan et al, [28] 2016

Malaysia

1

55/M

Right vallecula

Odynophagia and mild shortness of breath

Bochnia et al [29] 2016

Poland

1

-/-

 Left arytenoepiglottic fold 

Light dysphagia

Hui Zhu et al, [30] 2016     

USA

3

34/M     70/F   56/M

Left arytenoids

Hoarseness and difficulty breathing.
Dysphagia and difficulty breathing.
Difficulty breathing and swallowing

Hypopharyx

Posterior arytenoids and left piriform sinus           

Acquaviva et al, [31] 2016

Italy

1

63/F

Left piriform sinus

Severe dyspnea

Deutsch et al, [32] 2016

UK

1

62/M

Left laryngopharynx

Intermittent airway obstruction, dysphagia

Demir et al, [33] 2016

Turkey

1

34/-

False vocal fold

Hoarseness, globus sensation

Wolf-Magele et al, [34] 2016

Austia

1

-/-

Larynx

Stridor and dyspnea

Nada et al, [35] 2017

Tunisia

1

32/F

Left aryepiglottic fold

Changes in voice

Burkes et al, [36] 2019

USA

1

-/M

Larynx

Hoarseness, dysphagia, globus sensation, and neck fullness

Reid et al, [37] 2019

Canada

2

-/-

Larynx

Dyspnea, hoarseness and stridor

Azimivaghar et al, [38] 2019

India

1

68/M

Left glottic

Dysphonia

Azandaryani et al, [39] 2019

India

1

47/M

Left supraglottic larynx

Hoarseness, dyspnea and neck fullness

Okromelidze et al, [40] 2019

USA

1

51/M

Left vocal folds

Hemoptysis and sore throat

Yunxia et al, [41] 2020

China

1

70/M

Suglottic

Progressive dyspnea

Qin-Ying et al, [42] 2020

China

1

65/F

Left epiglottis

Pharyngeal paraesthesia

Lombardo et al, [43] 2020

Italy

1

28/F

Left aryepiglottic fold

Dyspnea

Azar et al, [44] 2021

USA

1

35/M

Supraglottic

Dysphagia and dyspnea

The elective treatment of a laryngeal lipoma is radical surgical excision to reduce the chances of recurrence. Depending on the size and location of the tumor, endoscopic removal, with or without CO2 laser, is indicated for lipomas smaller than 2 cm [36,37]. On the contrary, for non-pedunculated tumors or tumors larger than 2 cm, the definitive treatment is through an open technique with an external approach (thyrotomy, transhyoid pharyngotomy or lateral pharyngotomy) [36,38]. In the case exposed, the use of the TLM CO2 laser proved to be effective in granting a radical excision in the absence of bleeding or other complications. The use of the photocoagulation technique on the resection margins was employed in order to decrease the chance of recurrence [34].

Conclusion

Lipomas of the larynx are rare and often asymptomatic diseases. However, as their dimension increases, they might lead to life-threatening clinical situations, including airway obstruction. In the literature, 2 cm lipomas represent the maximum limit for the use of intraoral surgery. Beyond this dimension, the surgical approach with an open technique might find indication. The use of the TLM with CO2 laser made it possible to perform a less invasive surgery with a lower risk of bleeding, while granting a radical excision and a shorter hospitalization [26].

Authors' contributions: All authors contributed to data analysis and manuscript writing. All authors have reviewed and approved the final version of the manuscript.

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