Journal of Clinical Images and Medical Case Reports

ISSN 2766-7820
Clinical Image - Open Access, Volume 3

Florid squamous papilloma of the tongue

Jing-yao Liang1,2†; Chang-xing Li3†; Ping-jiao Chen3; Xi Bao Zhang1,2*

1 Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, P.R. China.

2 Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, P.R. China.

3 Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China.

*Corresponding Author: Xi Bao Zhang
Department of Dermatology, Guangzhou Institute of Dermatology, 56 Hengfu Road, Guangzhou 510095, P.R. China.
Email: [email protected]

Received : Feb 24, 2022

Accepted : Apr 20, 2022

Published : Apr 27, 2022

Archived :

Copyright : © Zhang XB (2022).

Citation: Jing-yao L, Chang-xing L, Ping-jiao C, Zhang XB. Florid squamous papilloma of the tongue. J Clin Images Med Case Rep. 2022; 3(4): 1810.

Clinical image description

A 47-year old Chinese woman presented with a 2-year history of multiple small flammulated papilloma-liked lesions on her tongue. She has noted an increase of the size and number of lesions within the past month, with significant harsh feeling, but the taste sensation is normal. The physical examination showed diffusely multiple, florid, and slight raised spots in different sizes, measuring from 1 to 3 mm in dimensions, appearing on the dorsal surface and lateral borders of the tongue (Figure 1A and 1B). Incisional biopsy of the lesion area showed papillary mucosal epithelial, dermal superficial collagen bundle and mucous matrix hyperplasia (Figure 1C). She denied any other cutaneous or systemic abnormalities. Based on histopathological examination, a diagnosis of squamous papilloma was made.

Squamous papillomais benign tumor, occurring anywhere of oralcavities of people ranging from 11 to 40 years old, which is clinically characterized by red or white verrucous, finger- or cauliflower-shaped lesions [1]. It is very rare disease and causative agent has not yet determined. The currently accepted pathogenesis includes human papilloma virus (HPV) infection, smoking, and chronic inflammatory. However, the tests for HPV evidence in this case were all negative in the samples of blood, saliva and lesions. She has never smoked the cigarette. Available therapeutic options for this tumor arephotodynamic treatment, systemicretinoid, chemotherapyand surgical excision [2].


Acknowledgments: This study was supported by the Science and Technology Program of Guangzhou (Grant No. 201904010191), the Characteristic Clinic Project of Guangzhou Health Commission (Grant No. 2019TS68), the Medical Science and Technology Research Foundation of Guangdong Province (Grant No. A2019464).

Disclosure: The authors declare no potential conflict of interest.

Figure 1: Squamous papilloma of the tongue. (A) and (B) Multiple small flammulated papilloma-liked lesionson the patient’stongue. (C) Biopsy showed squamous papilloma.


  1. Orenuga OO, A O, Oluwakuyide RT et al. Recurrent oral squamous papilloma in a pediatric patient: Case report and review of the literature. Niger J Clin Pract. 2018; 21(12): 1674-1677.
  2. Mahajan R, Kurien RT, Joseph AJ et al. Squamous papilloma of esophagus. Indian J Gastroenterol. 2016; 35(2): 151.