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A 28-year-old male presented to the emergency department with intractable vomiting and retrosternal chest pain on a background of poorly controlled type 1 diabetes mellitus. Laboratory investigations demonstrated a neutrophilic leukocytosis as well elevated blood glucose (18) and ketones (4.6), serum lactate was normal at 1.2.

Dulaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the treatment of type 2 diabetes mellitus which is typically prescribed as adjunctive therapy when lifestyle interventions and metformin alone are insufficient in controlling blood sugar levels.

Choriocarcinoma following a term pregnancy is a rare spectrum of gestational trophoblastic neoplasia, as most cases occur after a molar gestation. We present a case of a 35-year-old para 4, diagnosed with choriocarcinoma and lung lesions complicated by postpartum haemorrhage after a spontaneous delivery of a stillborn baby at term.

The ex-utero intrapartum treatment (ExIT) procedures are successfully used to approach many forms of foetal airway management problems at delivery, including neck masses, congenital high airway obstruction syndrome (CHAOS), intrathoracic and mediastinal masses, unilateral pulmonary agenesis and congenital diaphragmatic hernia (CDH).

Patient with heart failure with a calcified ventricular thrombus revealed by the x-ray, rare finding, and confirmed by echocardiogram.

Silicone breast implants rupture occur in 5.8% to 23.7% cases. Silicon-associated lymphadenopathy is a rare complication of an implant rupture due the migration of silicone particles to the lymph nodes.

A 68-year-old male construction worker presented with fever, cough, dyspnea, and known exposure to a confirmed COVID-19 case. Despite two consecutive negative RT-PCR tests, clinical presentation and elevated inflammatory markers raised high suspicion for COVID-19 pneumonia.

Ectopic thyroid is a form of thyroid dysgenesis and is defined as the presence of thyroid tissue in an abnormal location. Its prevalence is about 1 per 1,00, 000-3,00,000 people, rising to 1 per 4,000-8,000 patients with thyroid diseases. The most common sites of ectopic thyroid are lingual (90%) and anterior neck (10%).

Duodenal injuries by blunt abdominal trauma in children are rare. They are often missed because of the retroperitoneal position of the duodenum. Their diagnosis and treatment remain a challenge. We report the case of a 15-year-old adolescent suffering a blunt abdominal trauma due to a kick of horse.

Lymphangioma is a benign tumor with slow progression, most commonly affecting the head and neck. Orbital involvement is rare (1-2% of orbital tumors) but can be severe due to significant functional and cosmetic impairment, as well as the difficulty of surgical resection.

Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive malignancy of the paranasal sinuses. Among its molecular subtypes, SMARCB1-deficient SNUC represents a particularly aggressive variant with poor prognosis and distinct diagnostic and therapeutic challenges.

Breast cancer is the most prevalent cancer among women worldwide and the leading cause of cancer-related fatalities in females. Various factors contribute to breast cancer, including lifestyle choices and genetic predispositions.

Healthcare professionals, nurses and doctors often face the challenge that patients suffering from cancer experience decreased sexual health. The communication about sexual health is suboptimal. The objective of this study was to explore healthcare professionals’ attitudes, perceptions, and communication about sexual health issues among patients who have cancer.

A 1-month-old neonate with known atrial septal defect (ASD) and congestive heart failure (CCF) was referred to our centre for further evaluation through Computed Tomographic Angiography (CTA).

High-pressure injection injuries, though deceptively benign on initial appearance, can result in significant morbidity due to deep tissue involvement and rapid progression to compartment syndrome. We report a case of 64-year-old male quarry worker who sustained a high-pressure injection injury from a power washer to his middle finger of his right dominant hand.

Telangiectatic osteosarcoma (TOS) is an uncommon and aggressive variant of osteosarcoma with numerous blood-filled cystic spaces, leading to confusion with benign lesions like aneurysmal bone cyst (ABC). Early, accurate diagnosis is vital to starting appropriate management and improving overall outcomes.

Diastematomyelia, or split cord malformation, is a rare congenital spinal anomaly characterized by a longitudinal division of the spinal cord into two hemi cords, separated by a fibrous or bony septum. Typically diagnosed in childhood, adult presentation is infrequent and more common in females.

Systemic lupus erythematosus (SLE) is a chronic, multi-systemic autoimmune disease that can affect various parts of the body, including the eyes. Ocular findings are reported in about one-third of SLE patients and can be the initial manifestations of the disease, often complicated by going unnoticed.

Hepatic abscesses are rare in pediatrics and remain a poorly documented complication in patients with sickle cell disease. A 15-year-old boy with sickle cell disease presented with acute right upper quadrant pain and was diagnosed with multiple liver abscesses.

The ability to detect foreign bodies in the musculoskeletal system using conventional radiography relies on the variable absorption of X-rays by materials of different density and atomic number. Various types of metallic foreign body have been reported, including bullets, needles, metal splinters, screws, migrated surgical material.

A middle-aged diabetic female presented with acute headache, left eye ptosis, pain and ophthalmoplegia. The best corrected visual acuity in right eye was 20/20 and left eye was 20/200. Anterior segment evaluation was unremarkable. Extra- ocular movements in the left eye were restricted in all the gazes except levoduction.

We read with great interest the recent study by Al-Bakir et al., which explored the use of low-coverage whole-genome sequencing (lcWGS) to predict progression to advanced neoplasia in patients with Ulcerative Colitis (UC) and Low-Grade Dysplasia (LGD).

Toxoplasmosis is a well-established opportunistic CNS infection in HIV patients, most commonly manifesting as cerebral abscess or meningoencephalitis. However, isolated spinal cord involvement remains extremely rare. We report a case of a 48-year-old HIV- positive male presenting with progressive spastic paraparesis.

On February 24, 2022, with the start of a full-scale invasion, clinical trials inside Ukraine stopped. The implementation of evidence- based digital health solutions and patient-centric policy frameworks enabled accessible and sustainable care continuity for 451 clinical trial participants in times of conflict.

Pulmonary histoplasmosis poses a challenge to clinicians from both clinical and diagnostic perspectives. Epidemiologic clues and a careful exposure history, as well as patterns on chest imaging, may raise appropriate suspicion for the diagnosis.

Diabetic foot ulcers and neuropathy are significant complications of diabetes mellitus, leading to substantial morbidity. Conventional treatments can be challenging, necessitating the exploration of adjunctive therapies. Pulsed ElectroMagnetic Field (PEMF) therapy has emerged as a non-invasive modality with potential benefits in managing diabetic complications.

A 34-year-old woman presented to the clinic with severe muscle pain of both thighs and tea-colored urine for two days after spinning class. Physical examination found small dots and diffused rash around the popliteal fossa region of both legs (Figures 1A and 1B).

69-year-old immunocompetent man presented to the emergency department for COVID-19 infection and a lesion in the groin is noted during his hospitalization. Patient stated that he had this slow growing lesion for about 20 years but felt embarrassed to seek medical attention.

Accurate diagnosis of patients presenting with dyspnea when Heart Failure with Preserved Ejection Fraction (HFPEF) is suspected can be challenging. The proper diagnosis has significant implications for patient management.

We report a rare and complex case of left-sided Ebstein’s anomaly associated with congenitally corrected transposition of the great arteries (ccTGA), persistent left superior vena cava (PLSVC), and early fetal growth restriction (FGR), diagnosed prenatally at 25 weeks and 4 days of gestation.

A case of cholangitis caused by live Fasciola hepatica is presented. The patient, diagnosed with cholangitis, was treated with 10 mg/kg oral triclabendazole after the parasite was removed with endoscopy retrograde cholangiopancreatography (ERCP).

A young lady with a recent caesarean section presented with thunderclap headache and was diagnosed to have Reversible Cerebral Vasoconstriction Syndrome (RCVS). Soon after, she had tachycardia with troponin elevation. Cardiac imaging confirmed a diagnosis of Takotsubo Cardiomyopathy (TCM).

Venous Leg Ulcer (VLU) is an open skin injury of the lower limbs caused by persistent or Chronic Venous Insufficiency (CVI) and venous hypertension. It is a common type of chronic lower limb wound and accounts for 70%~80% of all chronic lower limb ulcers.

We describe a case in which a child with epilepsy developed dyspnoea and a continuous decrease in blood oxygen saturation after convulsion. The child’s symptoms were relieved after oxygen was provided. A complete chest CT revealed diffuse pulmonary infiltration.

Case of Takotsubo cardiomyopathy with domestic abuse as the cause of acute stress.

Chronic diseases often emerge from multifactorial pathogenesis and interconnected biological pathways, making single-target treatments insufficient for long-term control. Polypharmacologymodulating multiple targets with a single agent or combination therapy-offers a promising alternative.