Articles

Ibrutinib is a potent covalent inhibitor of Bruton’s Tyrosine Kinase (BTK), a downstream kinase of B cell receptor vital for B cell survival and proliferation. Ibrutininb is indicated to treat many types of B-lymphoproliferative disorders, including Mantle Cell Lymphoma (MCL). Ibrutininb is considered a well-tolerated drug, with a small side effect profile compared to chemotherapy.

Congenital teratomas are relatively rare neoplasms, which occurs in about 1:20,000 to 1:80,000 births, and only 1.5% to 5% of which are neoplasm of the cervical. They can be diagnosed through ultrasound during pregnancy and, if not properly handled, have a high mortality rate. Airway compression is a secondary complication following mortality.

We report a case of multiple metastatic prostate cancer. A 63- year-old man presented with both paraplegia with anesthesia following transuretral resection of prostate (TUR-P). 18F-fluorocholine positron emission tomography-computed tomography (18F-FCH PET/CT) and magnetic resonance imaging demonstrated multiple axial bone and pulmonary metastasis with multiple lymph nodes invasion.

Cardiac metastases from squamous cell carcinoma of the esophagus are rare but should be recognized when present. We report PET/CT findings in a 72-year-old lady with dysphagia and diagnosed with squa- mous cell carcinoma esophagus. PET/CT revealed uptake within the esophageal primary, and revealed multiple metastatic lesions, including an FDG-avid metastasis within the right ventricular myocardium.

The aim of the study is to investigate additional findings associated with tumor thrombus on F-18 FDG PET/CT other than intravascular metabolic activity such as direct or indirect extension with the primary tumor, association between metabolic activity of primary tumor & tumor thrombus and incidence of distant metastases.

Ventricular Septal Rupture (VSR) is rare but dreadful complication of Myocardial Infarction (MI). With medical treatment, mortality is very high. Even with surgery, the perioperative morbidity and mortality is high, though results are better than medical therapy. Device closure is less invasive than surgery and is a good alternative, especially in patients with cardiogenic shock.

Hydrocelectomy is a common and simple urological procedure which may sometimes develop complications. The majority of them are minor, but rarely more significant ones may have an intense clinical image. We present a case of immediate postoperative severe scrotal hematoma after hydrocelectomy that required surgical intervention in a young man.

We report the case of a 59-year-old Brazilian woman who sustained an injury to her right index finger when the cat she was caring for scratched her. She developed a tender, ulcerating, scaly lesion with a pustular component and surrounding erythema at the site of trauma. Secondary lesions consisting of dusky violaceous coloured nodules then appeared along the proximal lymphatics of the patient’s upper limb.

Genitourinary Tuberculosis (GUTB) represents a manifestation of extrapulmonary tuberculosis associated with significant urinary tract complications, such as contracted bladder and renal insufficiency. This report delineates a rare instance of GUTB culminating in considerable urological impairment, necessitating complex reconstructive procedures.

A 2050 gm, 34 weeks gestational age term female with a family history of Osteogenesis Imperfect (OI) was referred for ROP Screening. She was on oxygen support for respiratory distress. On examination, both eye sclera showed blue-grey discoloration (Figure 1). Fundoscopy of both eyes showed Stage 1, Zone II Retinopathy of Prematurity (ROP) (Figure 2).

A 27-year-old male with a long-standing history of chronic otitis media developed a right temporal cerebral abscess. He underwent a mastoidectomy and was treated with intravenous antibiotics, including metronidazole. The patient’s clinical condition showed signs of improvement.

Diffuse inflammatory polyposis of the colon is a rare finding in Inflammatory Bowel Disease (IBD). Herein we describe a unique case of diffuse giant inflammatory polyposis in a 39-year-old women, admitted to the department of surgery for undetermined pancolitis without history of IBD.

Assessing auditory nerve excitability is crucial in determining candidacy for Cochlear Implantation (CI). Pre-operative tests, such as Electrical Auditory Brainstem Response (EABR), are utilized to evaluate the function of the auditory pathway. However, uncertainties about auditory pathway excitability may persist despite these tests.

To evaluate the effect of the consumption of juçara and açai beverages on appetite. A randomized pilot double-blind and crossover study was conducted with sixteen healthy adults who were submitted to two trials, a beverage with acai or juçara. Immediately after ingestion, we assessed the satiation, hunger, and desire to eat using the Visual Appetite Scale (VAS) and the Overall Appetite Score (OAS).

We are writing this letter to address a rarely talked about topic referencing the need of sterilisation in intellectually disabled females. The World Health Organization defines Intellectual Disability (ID) as “a state of arrested or incomplete development of mind, which means that the person can have difficulties understanding, learning, and remembering new things, as well as applying that learning to new situations” [1].

A 47-year-old female presented with reduced left visual acuity of 6/18 and metamorphopsia. She was found to have a fullthickness central macular hole (Figure 1A). Surgical repair was planned, however one week prior to scheduled surgery the hole had spontaneously closed (Figure 1B).

Desmoid-type Fibromatosis (DF) is a rare and locally aggressive tumor that occurs predominantly between puberty and 40 years, with female predominance. The aim is to clarify the DF management. A 30-year-old woman who had a large desmoid fibromatosis tumor of here left buttock with 2 years history of local pain. MRI showed a well defined and lobulated tumor mimicking a man face.

Small cell neuroendocrine carcinoma is a rare malignancy that mainly affects the pulmonary tract and only occurs extrapulmonary in very few cases, accounting to about 2.5-5% of all cases [1,2]. Primary sinonasal neuroendocrine carcinoma is extremely rare and typically affects the ethmoid or maxillary sinuses, with or without concomitant involvement of the nasal cavity [3].

Vestibular schwannomas (VS) are benign tumors that originate in the Schwann sheath of the vestibular nerve and constitute 6-8% of primary intracranial tumors. Intracanalicular vestibular schwannomas (IVS) are rare entities, usually identified by MRI, and they arise from the intracanal route and progress toward the cerebellopontine angle.

Clubbing of the digits has been recognized as a clinical sign of variety of diseases from earliest of the times. Digital clubbing was first ever reported in a patients with empyema by Hippocrates himself. Since then, digital clubbing has been associated with various underlying pulmonary, cardiovascular, neoplastic, infectious, hepatobiliary, endocrine, and gastrointestinal diseases.

Panic disorder symptoms may be confused with temporal lobe epilepsy findings. In this study, it was determined that the complaints of an male adult patient with panic disorder for 4 years were associated with temporal lobe epilepsy. Partial-onset seizures presenting with panic attack symptomatology can pose a diagnostic challenge. It will be beneficial for clinicians to keep in mind the sensory seizure due to epilepsy while taking the case history of panic symptoms.

Abnormal embryological development of the Mullerian ducts results Mullerian duct anomalies, which are congenital defects of the female genital system. The female genital tract and the urinary tract are closely related anatomically and embryologically and it has been reported that about 10% of infants are born with some genitourinary system abnormality.

Hypercalcemia is a critical and urgent clinical condition that can lead to death, related to blood calcium levels. We present a case of a 69-year-old female who presented with respiratory and renal failure, depression due to iatrogenic hypercalcemia developing in a patient using uncontrolled calcium and vitamin D.

To report a case of vulvar leiomyosarcoma. Medical record analysis and literature review at scientific Database. MP, a 48-year-old female, presented with a 3-month history of a ten-centimeter vulvar mass on the left major labia, adhered to a deep plane, and associated with local pain (Figure 1).

Lipoma are benign adipose tumor which usually present in the subcutaneous tissues. Lipomas are characterized as slow-growing, soft, mobile, round and asymptomatic masses on the head, neck, shoulders, and the back. They usually develop between the ages of 40-60. Apart from these common locations this universal benign tumour can be observed at some rare location is planter aspect of foot [1].

Dilated cardiomyopathy is an etiologically heterogeneous myocardial disease characterized by left ventricular or biventricular dilation with systolic dysfunction in the absence of hemodynamic overload factors (hypertension, valvular defects, congenital heart anomalies) or coronary pathology (ischemic heart disease) [1]. Dilated cardiomyopathy can develop at any age but is more common in young people.

Cytosteonecrosis (CSN) is a rare pathology that is poorly described in the medical literature. Its pathogenesis is still poorly elucidated, and it generally develops in the neonatal period. Diagnosed clinically, it presents as indurated, purplish skin patches on fair skin or hyperchromic patches on black skin, often localized on the face, trunk, buttocks and roots of limbs.

Less than 1% of head and neck malignancies are Parapharyngeal Space (PPS) tumors; salivary gland tumors make up the majority, followed by tumors with a neurogenic origin [1]. Despite being the most prevalent benign mesenchymal tumors of the head and neck, lipomas are not frequently seen in the PPS [2].

31-year-old woman with symptomatic uterine fibroids who underwent open myomectomy. Despite prior treatment with goserelin, persistent symptoms and desire for future fertility warranted surgical intervention. The surgical technique aimed to optimize hemostasis and minimize morbidity by employing fusiform incisions.

Monoclonal gammopathy of renal significance is defined as kidney injury due to underlying immunoglobulin-secreting plasmacell or B-cell clone. Here, we report the case of a patient with incomplete Fanconi Syndrome diagnosed two months after Kidney Transplantation (KT), which revealed crystalline k-Light-Chain Proximal Tubulopathy (LCPT) on the kidney biopsy.

Patient aged 54 years, operated on 4 months ago for gastric adenocarcinoma, currently undergoing adjuvant chemotherapy, presenting with paresis of the lower limbs. An MRI of the lumbar spine was performed, revealing a sequestrated extra-dural mass adjacent to the vertebral bodies of L5, S1, and S2, with a median, para-median, and left foraminal position.

Periprosthetic fractures are a well-recognized complication of joint arthroplasty, with an increased risk in the long-term follow-up of joint replacements. In a long-standing bipolar hemiarthroplasty case, we highlight the management challenges of a displaced periprosthetic fracture and difficult implant removal.

Vascular anomalies are incidental findings revealed by imaging techniques such as Computed Tomography Angiography (CTA), ordered for various medical reasons. Certain variants have been observed and reported more frequently than others, while some occur infrequently. A 63-year-old patient with a medical history of hypertension, atherosclerosis and smoking but no other symptoms such as chest pain or abdominal pain, was consulted by a vascular surgeon.

Basal cell carcinoma is the most common malignant cutaneous tumor in humans. It can occur in any area of the body surface, but predominates in photo-exposed areas, particularly the face and trunk. Its main cause is chronic exposure over the years to ultra violet radiation, ionizing radiation, chemical carcinogens The occurrence of metastases is extremely rare.

21-year-old male presented to our pulmonology clinic with complaints of abdominal discomfort for 2 weeks. He had history of seizures since childhood well-controlled with anti-epileptic medications. Patient had lesions on face and back on physical examination (Figure 1A & 1B).

A 6 mm defect is seen over anterior aspect of face in between both orbits with a 2.6 x 2.5 cm sized cystic collection herniating through the defect possibly arising from ethmoid s/o Ethmoidal encephalocele. CSP (Cavum Septum Pellucidum) is not well visualised with bilateral parallel orientation of lateral ventricles.

To obtain real world data on the efficacy, safety and performance of a Hypertonic Seawater Solution comprising Algal Extracts and Dexpanthenol (HSSAll) indicated for Allergic Rhinitis (AR), we have conducted a user survey study in a total of 300 adult and pediatric patients recruited in 2 hospital centers over a period of 9 months.

Sporotrichosis is a subacute or chronic mycosis caused by a thermodimorphic fungus of the genus Sporothrix. It is considered a cosmopolitan disease, mainly in tropical and subtropical regions, and is endemic in Latin America. In Brazil, there are two modes of transmission to humans: traumatic inoculation with contaminated soil and organic matter and zoonotic transmission (infected felines).