Articles

Volume-3, 2022
Issue 8 (Aug)



A case of thoracoscopic-assisted tracheal tumor resection and tracheal reconstruction

Primary tracheal tumor is a disease with low morbidity and poor prognosis. Surgical resection is the main treatment. It is difficult to treat tracheal tumors, while involving tracheal reconstruction operations are more complicated. We report a case of tracheal tumor patient. The large tumor was located above the tracheal carina and the opening of the left main bronchus.

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A case of PTPN11 mutation-related Noonan syndrome

Noonan Syndrome (NS) is an autosomal dominant disorder in which parents with Noonan syndrome have a 50% chance of passing the mutation to their children, most commonly due to a mutation in the PTPN11 gene. In a clinical case, we identified a male child who showed clinical features such as short stature, congenital heart disease and a peculiar facial appearance, strongly suspecting Noonan syndrome.

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Atypical caudal regression syndrome with lumbar agenesis, hypoplastic sacrum without sacro-iliac joints in the Eastern Democratic Republic of Congo: A case report

Lumbosacral agenesis is a rare and complex malformation characterized by a total or partial absence of the lumbosacral vertebrae. It is often associated with other congenital malformations. Its etiology is poorly understood but factors such as gestational diabetes, genetic abnormalities and environmental factors are incriminated.

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An unusual presentation of a neuroblastoma

Neuroblastoma (NB) and Wilms tumor (WT) are very common tumors of the pediatric patient and can be sometimes difficult to make a differential diagnosis based only on the imaging findings. We present the case of a little patient who presented to our department with an abdominal mass in the left abdominal region, where the lesion presented elements at imaging which led to the diagnosis of a WT in a context of negativity of the urinary catecholamines.

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IgG4-related lung disease: A case report and literature review

IgG4-Related Lung Disease (IgG4-RLD) is an unusual disease, having various clinical manifestations. Patients may have no respiratory symptoms and no abnormalities shown on chest images. Therefore, the diagnosis is challenging. Here we present an uncommon case of IgG4-RLD with multi-loci nodeson the center of the hilar and review the relevant literature.

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A unique pitfall of myocardial perfusion imaging in transthyretin amyloid cardiomyopathy

Myocardial Perfusion Imaging (MPI) is a non-invasive modality with proven diagnostic and prognostic utility in coronary artery disease. We present a case of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) where MPI findings were vastly different from Transthoracic Echocardiogram (TTE) and Cardiac Magnetic Resonance Imaging (CMR). A 78-year-old gentleman presented with atypical chest pain to rule out ischemic heart disease.

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Severe pulmonary mucorales superinfection in three influenzapatients with and without influenza-associated aspergillosis

Mucormycosisis an opportunistic fungal disease which affects immunocompromised hosts including patients with haematologic malignancies and poorly controlled diabetes mellitus. Mucorales grow invasively and are associated with high mortality even if promptly diagnosed. Viral infection like influenza can cause severe pneumonia and is associated with pulmonary aspergillosis.

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Three-dimensional assessment of human enamel surfaces after adhesive resin removal using CLSM - an in vitro study

The aim of this study was to evaluate the effects of three different methods of adhesive resin removal on the enamel structure using a confocal laser scanning microscope (CLSM). Initially, the enamel roughness of 39 extracted molars was determined using CLSM and the surface roughness parameters Sa, Sq and Sz were obtained. Subsequently, self-ligating metal brackets were applied using the composite Transbond XT.

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A case series of different courses of methotrexate-associated lymphoproliferative disease with pulmonary involvement

Lymphoproliferative Disorder (LPD) is a complication of Methotrexate (MTX) therapy. Several cases of Methotrexate-Associated Lymphoproliferative Disorder (MTX-LPD) have been reported. However, pulmonary lesions in MTX-LPD are rare. Image findings of MTX-LPD show various patterns. Pneumocystis pneumonia and interstitial pneumonia, which have complex courses, have been reported in MTX-treated patients with lung diseases other than MTX-LPD.

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Microwave radiations of environment: On the possibility of inhibition of malignant mitosis

From the standpoint of fundamental physical optics, clinical images and medical cases of a number of human viral diseases are considered under the influence of the environment on a sick organism, namely: Solar-geomagnetic disturbances and modern anthropogenic background. Microwave emission of the terrestrial ionosphere disturbed by flares on the Sun and during periods of magnetic storms was determined to be the agent of such an impact.

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Digital communication through COVID: A free NHS app for patients with type 1 diabetes improves accessibility and self-management

Self-management of chronic disease is increasingly being recognised as an essential tool in chronic disease management. During the pandemic, face-to-face diabetes clinics were suspended, and resources were focussed on delivery of urgent care only. A free NHS app was created to virtually deliver information on every aspect of type 1 diabetes management and to promote patient self-management.

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The role of “smart-flap” of sternocleidomastoid muscle in cervical spine surgery: A proposal of a new surgical technique

In cervical spine surgery there are known risk of complications such as esophageal fistula and dural tear. Usually the gold standard in treatment is represented by surgery. The sternocleidomastoid flap is the most common used in the revision procedure. In this paper we propose a modified surgical technique of harvesting the SCM flap and we suggest its use as prevention in selected cases.

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Biomechanical invasive reconstruction of the distal oblique band of the interosseous membrane with extensor carpi radialis longus in radioulnar instability: A new clinical therapy for athletes

Distal Radioulnar Joint (DRUJ) instability is a pathology without a clear reconstructive procedure. Throughout history, numerous techniques have been described whose objectives have been to increase stability as well as relieve pain. The main stabilizing element is the Triangular Fibrocartilage Complex (TFCC) and, there are also secondary stabilizers among where the Distal Oblique Bundle (DOB) is consistently located.

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Post-COVID-19 polyautoimmunity (pancytopenia, hypothyroidism): A case report

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated pancytopenia and hypothyroidism are known but rare complications of COVID-19 syndrome that are not well described in literature, particularly when manifested simultaneously. Severe acute respiratory syndrome coronavirus 2 has shown the potential to affect any organ including the hematopoietic and endocrine system

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Congenital toxoplasmosis: About a serious and preventable case

Congenital toxoplasmosis results from vertical transmission of the Toxoplasma gondii parasite from mother to fetus after a primary maternal infection. The risk of fetal contamination is higher the later the term of maternal infection. Conversely, the risk of severe fetal infection decreases with term; third trimester infections are most often asymptomatic at birth.

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Binder’s syndrome and its management in a tertiary hospital

Binder’s Syndrome or Maxillonasal dysplasia is an uncommon condition that presents as retrusion of the midface. This varies in severity, ranging from minor involvement of the nose to severe hypoplasia of the maxillary complex. Depending upon the severity, different types of procedures are required. In this paper we present our experience with managing such patients.

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Late diagnosis of Neural Tube Defects: About two uncommon cases

Neural tube defects are pathologies of the central nervous system occurring between the 23rd and 27th day of embryonic life. Classified into two groups: cephalic pole anomaly (anencephaly) and spinal pole anomaly (spina bifida), these are uncommon anomalies representing one case per 1000 births, often resulting in therapeutic termination of pregnancy.

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A rare case of uterovaginal prolapse and concomitant vaginal carcinoma

Uterovaginal prolapse and concomitant primary vaginal carcinomas are extremely rare. We present a case of 70-year-old woman who had uterovaginal prolapse for 4 years and complained one episode of post-menopausal bleeding. There was a large cystocele, third degree uterovaginal prolapse with large fungating growth confined to the upper and mid vagina.

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Research status of vitiligo models

Vitiligo is a multifactorial autoimmune disease characterized by depigmentation of the skin and mucous membranes. The etiology and pathogenesis of vitiligo are not yet fully understood. The establishment of suitable vitiligo models will facilitate studies of the pathogenesis and therapeutic treatments of vitiligo.

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Seeing the outside, remember the inside – A rare cutaneous manifestation of pancreatitis

We present a case of a 70-year-old man with recurrent abdominal pain for one month, which preceded the onset of erythematous tender nodules over bilateral lower limbs. After full history-taking and extensive investigations, he was subsequently found to have chronic pancreatitis with a pancreatic duct stone. Skin biopsy of the nodules showed lobular panniculitis and in the setting of high serum amylase.

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Cutaneous sweat gland carcinoma of supra-pubic region

Cutaneous sweat gland carcinoma is an extremely rare malignant skin cancer which may arise from the apocrine or eccrine types of sweat glands. It has a high mitotic index and malignant potential and usually occurs in the elderly people, without any gender predilection.

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Penetrating neck trauma with laryngeal exposure: A case report

Penetrating neck trauma are defined as injuries deeper to the platysma, and is associated with serious complications because of its high density of vital structure contents. The fast establishment of a secure airway is the first priority of management, especially in patients with laryngotracheal insults that carries high risk of airway compromise.

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A moderna mRNA-1273 COVID-19 vaccine induced pityriasis rubra pilaris

Pityriasis rubra pilaris (PRP) is a papulosquamous disorder of unknown aetiology. We report the first case of PRP induced by the Moderna mRNA-1273 COVID-19 vaccine. A 63 year old male presented with a new onset papulosquamous eruption 2 weeks after his second dose of the Moderna COVID-19 vaccine. He underwent a skin biopsy which showed psoriasiform dermatitis but continued to progress despite topical corticosteroid treatment.

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microRNA-155 as a potential biomarker in early detection of breast cancer: A meta-analysis

Breast cancer is one of the leading malignancies in women worldwide. Early detection of breast cancer could be the best strategy to hold on to cancer and save lives. Circulatory microRNAs are the most dominant method for diagnosis and monitoring cancers. Here in this study, we aimed to see the potential of miR-155 as a diagnostic biomarker for breast cancer early detection.

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Walnut consumption as a cause of black tongue: A case report

Extrinsic stain and black hairy tongue need to be considered in the differential diagnosis of discoloration of the tongue. Both are benign conditions, characterized by altered coloration of the dorsum of the tongue. However, they differ in the macro- and microscopic appearance, with black hairy tongue presenting with hypertrophy and elongation of the filiform papillae.

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Low-intensity pulsed ultrasound in the treatment of delayed-union: A case report

Failure of bone fracture healing is quite common and between 5% and 10% of bone fractures are associated with delayed or nonunion. The aim of this case report is to draw attention to the management and the potential solutions of this problems. We report a case in which we successfully used low-intensity pulsed ultrasound (LIPUS) in a 40-year-old Caucasian woman with a delayed union of both bone forearm.

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Cervical spinal cord tetraplegia in adults is not only post-traumatic. About 28 cases

Tetraplegia is paralysis of all four limbs. It is due to a lesion, partial or complete, of the spinal cord, most often at the cervical level. We carried out a retroprospective study over a period of 55 months (4 years and 7 months), from June 01, 2017 to December 31, 2021 from the files of patients referred for assessment by magnetic resonance imaging (MRI) in a context of sensorimotor deficit of the four limbs.

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A case of catatonia

A 67 year old lady presented with increasing lethargy and worsening of performance of activities of daily living. She was haemodynamically stable and investigations were unremarkable except for mild dehydration and high INR. She was admitted for further management. She remained well, until she was noticed to have deteriorated in GCS (responsive to pain).

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Post-covid lung recovery through physiotherapy: A case report

SARS COV 2 infection causes lung lesions characterized by the appearance of ground glass opacities, and a significant percentage of patients present persistent symptoms and changes in CT scan represented by fibrotic lesions, traction bronchiectasis, persistence of ground glass images. Laser therapy has anti-inflammatory effects, stabilizes the vascular endothelium, has antifibrotic effects.

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Imperforate hymen causing hematometrocolpos and acute urinary retention

The imperforate hymen is the result of a failure in the canalization of the vaginal plate, with an incidence of 1 in 2000 live births of women. Imperforate hymen can complicate with hematocolpos or hematometrocolpos. Common clinical manifestation is a periodic and long-lasting abdominal pain, enduring months to years before diagnosis.

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