Articles

Volume-5, 2024
Issue 2 (February)



Hyperimmune anti-CMV globulins and roxadustat for treatment of Parvovirus B19-associated anemia in kidney transplant recipients - A step ahead compared to intravenous immunoglobulins?

Parvovirus B19 (PVB19) may cause refractory and severe anemia in kidney transplant patients. Cellular tropism of PVB19 is associated with suppression of the red blood cell population, targeting erythroid progenitor cells, leading to persistent pure red cell aplasia with preserved leucocytes and platelets.

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IgG4-related pleuritis mimicking tuberculous pleurisy

A 55-year-old Japanese woman with a medical history of uterine fibroids presented with dyspnea on exertion for three months. She did not have so-called B symptoms such as weight loss or night sweats.

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A male with urinary bladder giant stone

86 years old male patient with antecedent of traumatic fracture of the spine and paraparesis state, 2 months ago presents dysuria, frecuency, vesical tenesmus, urinary retention and progression to anuria associated to abdominopelvic pain with irradiation to the lumbar zone.

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Cat scratch disease

Cat Scratch Disease (CSD), caused by the Gram-negative bacterium Bartonella henselae, presents a clinical challenge as a zoonotic infection. Named for its typical mode of transmission through scratches or bites from infected felines most commonly by domestic cats or kittens. C

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Vulvar squamous cell carcinoma with a fatal outcome

Vulvar cancer is one of the least common forms of gynecologic malignancies. At least 75 percent of vulvar cancer are squamous cell carcinoma, being mainly associated with human papillomavirus infection. Many patients are asymptomatic at the time of diagnosis. However, some have vulvar pruritus or bleeding.

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Rhinoscleroma: Hard tumefaction of respiratory mucosa- A clinical picture

A 34-years male, presented with left-sided nasal obstruction with mucoid nasal discharge for 3 months duration. On examination, there was a deviated nasal septum towards the right with a reddish fleshy mass in the left nasal cavity. There was decreased fogging on the cold spatula test on the left side and Cottles test was negative.

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Experience using etanercept off-label in toxic epidermal necrolysis in a tertiary care hospital

Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS/TEN overlap syndrome are rare, severe cutaneous adverse reactions usually triggered by medications. In addition to supportive care, various systemic therapies have been used including glucocorticoids, Intravenous Immunoglobulins (IVIGs), cyclosporin, N-acetylcysteine, thalidomide, infliximab, etanercept, and plasmapheresis.

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Carcinoma squamous cell, are healthcare professionals prepared to identify it?

Squamous Cell Carcinoma (SCC), is a type of cancer that originates in the squamous cells of the skin and has different stages according to the involved cellular layer. In the early stage, the process begins with chronic sun exposure, leading to DNA damage in the squamous cells of the epidermis.

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Presentation of multiple myeloma through cranial pair atrophy

Multiple Myeloma (MM) accounts for 1% of all cancers and approximately 10% of all hematologic malignancies. The diagnosis of multiple myeloma requires the presence of one or more Myeloma Defining Events (MDE) in addition to evidence of either 10% or more clonal plasma cells in bone marrow examination or a biopsy-proven plasmacytoma.

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Gabapentin-induced congestive heart failure

A 60 year-old man presented with acute congestive heart failure and atrial flutter 7 days after taking gabapentin prescribed for peripheral neuropathy. Gabapentin was discontinued and he became asymptomatic after standard therapy for heart failure and atrial flutter ablation.

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Capnocytophaga canimorsus: Clinical image

A 61-year-old man, with no known comorbidities, came to the emergency room on foot because of shortness of breath and chest pain while lying down, abdominal pain and fever with chills 38°C.

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Recurrent rhinosporidiosis: A clinical picture

28 year, male, driver by profession and resident of Kerala presented with complaints of recurrent Left nasal obstruction and intermittent epistaxis from left nostril of 6 months. He had underwent four excisional surgeries since last 3 years for same complaints.

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Traumatic anterior lens dislocation management

We report the case of a 52 year old man with no notable medical history with a setting of track road accident with blunt trauma to the righteye. The patient developped a red and painful right eye prompting him to present himself to our emergency room five days later.

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An unusual instance of traumatic occult pharyngeal fistula

Pharyngeal fistula is the most frequent complication after total laryngectomy, which is rare to occur in closed trauma and is also rarely reported in China. Traumatic pharyngeal fistula is a severe and rare disease that remains a diagnostic challenge nowadays.

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Multirecurrent hyperparathyroidism due to parathyromatosis

Parathyromatosis is an extraordinary singleton condition, which is characterized by hyperfunctional parathyroid foci, mainly delineated in the neck, mediastinum, and generally in the transplantation site, if the cause is related to previous surgeries.

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A complex case of severe acute hepatitis with cholestasis in a genetically predisposed woman: Could curcumin be the trigger?

Drug-Induced Liver Injury (DILI) can present as cholestatic hepatitis and differential diagnosis with other etiologies is often challenging. The established trend of growth in consumption of Herbal Dietary Supplements (HDS) by the general population underlines the necessity of timely suspicion and early recognition of its complications.

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Role of endoscopic ultrasound in diagnosis of unexplained distal common bile duct structure

Determining the etiology of a distal biliary stricture without an identifiable mass on imaging is crucial to the provision of appropriate therapy. This study aims to assess the ability of Endoscopic Ultrasound (EUS) to diagnose distal biliary strictures for which cross-sectional imaging modalities such as Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI) could not detect a causative mass or bile duct thickening.

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Diabetic myonecrosis with bilateral psoas inflammation

A 37-year-old male with a 30-year history of type 1 Diabetes Mellitus (DM) was hospitalized for acute onset of left lower extremity stiffness and significant myalgias limiting ambulation and standing up from a sitting position.

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Aortic pseudoaneurysm – Something fishy!

Accidental ingestion of a fishbone, rarely, when impacted in the esophagus, can cause an unusual range of complications from esophageal perforation to rare catastrophic vascular injuries like aortic pseudoaneurysm and aortoesophageal fistula, necessitating management on an emergency basis with computed tomographic angiography.

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Zinner syndrome in pediatric age: Clinical image

Zinner Syndrome (ZS) is a rare genitourinary malformation characterized by the triad of unilateral seminal vesicle cyst (QVS), ipsilateral Multicystic Displastic Kidney (MCDK), and obstruction of the ejaculatory duct. This condition is rare in pediatric age and both diagnosis and treatment are challenging.

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Primary catastrophic antiphospholipid syndrome in children with midbrain infarction: A case report

Catastrophic Antiphospholipid Syndrome (CAPS) is a multi-system autoimmune disease characterized by extensive thrombosis. Pediatric CAPS is extremely rare and associated with a high mortality rate, especially when midbrain infarction is involved. Hence, early diagnosis and prompt initiation of appropriate treatment for CAPS complicated by midbrain infarction are of utmost importance in achieving favorable outcomes.

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Giant cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma is the second most common type of skin cancer after basal cell carcinoma [1]. Of all non melanoma skin cancers, it accounts for 20% to 25% and its mortality is up 1.5 to 3.4% [2].

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Brucellosis presenting as mononeuritis multiplex

Brucella infection is common and causes central and peripheral nervous system disorders. The peripheral nerve involvement is usually a symmetrical sensorimotor polyneuropathy. Guillain-Barre Syndrome and carpal tunnel syndrome have also been described in brucellosis. There is no description of mononeuritis multiplex in this infection.

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A tale of noisy airways: Asthma or not?

A young female in her early twenties presented with complaints of sneezing, nocturnal dry cough, chest tightness and occasional nocturnal wheeze. She reported occasional reflux symptoms. She denied loss of weight, loss of appetite or fever. She gave a history of biomass fuel exposure.

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Incontinentia pigmenti - One case, two diagnoses

Incontinentia pigmenti is a rare X-linked genodermatosis caused by mutations in the IKBKG gene. It is a systemic disease mainly involving tissues of ectodermic origin, manifesting itself primarily as skin lesions but also as changes in the hair, nails, teeth, breasts, eyes and nervous system.

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Huge hydrocele in patients with COVID-19: A case series

Medical and surgical priorities have changed dramatically at the time of this pandemic. Scientific societies around the World have provided rapid guidance, underpinned by the best knowledge. A valuable, on the adaptation of their guidelines recommendations to the current situation.

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Unusual manifestation of pancreatic cancer in a young patient

Pancreatic cancer, often described as the most devastating among cancers, characterized by a malignant tumor with a grim prognosis and a limited response to systemic therapy. Its characterization is common in old age and very rare and unusual in the young age.

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